new homogeneous and robust catalyst for heck and suzuki reactions

Authors

b. mirza

m. h. sayahi

abstract

in this work, different ethyl 2,4-dioxo-4-arylbutanoate derivatives were prepared and evaluated for their src kinase inhibitory activity. for this purpose, the appropriate substituted acetophenone derivatives reacted with diethyl oxalate in the presence of sodium ethoxide in dried ethanol to give the corresponding products. all compounds showed moderate activities comparing with staurosporine as the reference drug.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

New Homogeneous And Robust Catalyst for Heck and Suzuki Reactions

In this work, different ethyl 2,4-dioxo-4-arylbutanoate derivatives were prepared and evaluated for their Src Kinase inhibitory activity. For this purpose, the appropriate substituted acetophenone derivatives reacted with diethyl oxalate in the presence of sodium ethoxide in dried ethanol to give the corresponding products. All compounds showed moderate activities comparing with staurosporine a...

full text

New Homogeneous And Robust Catalyst for Heck and Suzuki Reactions

A novel and efficient palladium-based homogeneous catalyst was fabricated and used as a robust catalyst in Suzuki–Miyaura cross-coupling and Heck reactions. 2-Amino-N(pyridin-2-ylmethyl)benzamide was introduced as a versatile ligand for palladiumcatalyzed cross-coupling reactions. The desired active and stable homogeneous Pd catalyst was prepared via the coordination of Pd with 2-amino-N-(pyrid...

full text

Synthesis of novel tridentate ligand-based palladium catalyst and investigation of its reactivity towards Suzuki, Sonogashira and Heck coupling reactions

We have demonstrated a simple and efficient route for the synthesis of a novel imine based tridentate ligand and its Pd-complex to investigate the C-C cross-coupling reactions, that involve column chromatography purification in only one step. The catalytic activity of the newly synthesized catalyst was studied for the Suzuki, Sonogashira and, Heck cross-coupling reactions under mild conditions....

full text

Aminophosphine palladium pincer complexes for Suzuki and Heck reactions

The aminophosphine-based pincer complexes [C6H3-2,6-{NHP(piperidinyl)2}2Pd(Cl)] (2) and [C6H3-2,6-{OP(piperidinyl)2}2Pd(Cl)] (3) are readily prepared from cheap starting materials by sequential addition of 1,1′,1′′-phosphinetriyltripiperidine and 1,3-diaminobenzene or resorcinol to solutions of [Pd(cod)(Cl)2] (cod = cyclooctadiene) in toluene under N2 in 'one pot'. Compounds 2 and 3 proved to b...

full text

Immobilized Palladium-pyridine Complex on γ-Fe2O3 Magnetic Nanoparticles as a New Magnetically Recyclable Heterogeneous Catalyst for Heck, Suzuki and Copper-free Sonogashira Reactions

A new immobilized palladium-pyridine complex on γ-Fe2O3 magnetic nanoparticles was synthesized and characterized by SEM, TEM, TGA, ICP, XPS, XRD, FT-IR and CHN analysis. The catalytic activity of synthesized catalyst has been investigated in Heck, Suzuki and Sonogashira coupling reactions using a series of aryl halides. The catalyst was easily isolated from the reaction mixture by an external m...

full text

Polyionic polymers – heterogeneous media for metal nanoparticles as catalyst in Suzuki–Miyaura and Heck–Mizoroki reactions under flow conditions

The preparation of monolithic polyionic supports which serve as efficient heterogeneous supports for palladium(0) nanoparticles is described. These functionalized polymers were incorporated inside a flow reactor and employed in Suzuki-Miyaura and Heck cross couplings under continuous flow conditions.

full text

My Resources

Save resource for easier access later


Journal title:
journal of sciences, islamic republic of iran

Publisher: university of tehran

ISSN 1016-1104

volume 26

issue 4 2015

Keywords
[ ' e t h y l 2 ' , 4 , ' d i o x o ' , 4 , ' a r y l b u t a n o a t e s ' , ' s r c k i n a s e ' , ' c a n c e r ' ]

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023